There's one situation where it does make a big difference to me - in manual with auto ISO. I adjust shutter and aperture using the modal dials, and tweak exposure with the exposure comp dial with the ISO floating. Not all cameras do this 'right', but Sony's A7 series does. Combined with WYSIWYG through an EVF it works really very well indeed.I'm simply finding modal twin dials (for thumb and forefinger) more useful. In Manual mode they can be Aperture and Shutter Time.
In AperturePriority or Shutter Priority they can be either - plus exposure compensation.
Matter of preference really. Some might like the dedicated exp-comp dial... I see them as a waste of a wheel by now