Micro 4/3 Olympus 100-400 vs 300 Pro

Robin hits the nail on the head. Use the right settings and use the right technique for long lenses. From what I've read of other users' comments, the 300 f4 Pro is sharper than the 100-400, but you'd expect it to be. At almost twice the price, it better be. :) OTOH, the 40-150 f2.8 Pro+MC-20 is not better than the 100-400, at least in my experience, and it doesn't reach 400. I dunno how good the 300 f4 Pro+MC-14 is, because I don't have the lens, but I figure it'd still be very good. I have the 100-400 and am satisfied with it. I prefer a zoom to a prime for a long lens for its versatility. I've even used the MC-14 with the 100-400 for good results. Check out Tom Stirr's photos with the 100-400. Small Sensor Photography by Thomas Stirr
 
I dunno how good the 300 f4 Pro+MC-14 is, because I don't have the lens, but I figure it'd still be very good.
It's really very good with no obvious image degradation using the MC-14. A lot of 300mm Pro users have the MC-14 mounted as the default use case, myself included. Without going to shooting charts I would say the 150-400mm is even sharper.
OTOH, the 40-150 f2.8 Pro+MC-20 is not better than the 100-400, at least in my experience, and it doesn't reach 400.
The advantage of the 40-150mm Pro + MC-20 is compact carrying. It's not my first choice for serious shooting but very handy to throw into a sling bag when running errands or going for a walk.
 
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