Hello and thank you! I hope that you like your new camera and are inspired to take some great images with it.
I think that I have my NX300 set up fairly simply. I use Aperture Priority (A) mode just about 100% of the time and just use the raw files to process in Lightroom but if you want to use the wifi connectivity of the NX300 to upload files directly from the camera I think that you would need to also shoot in jpeg.
I set "Framing Mode" to Off so that I always see the correct exposure of the final image and can see the effects of exposure compensation.
My Auto ISO limits are set between 100 and 3200. The NX300 has a very comprehensive menu for customising the Auto ISO parameters, which I wrote about in this thread:
https://www.photographerslounge.org/threads/22960/.
For quick access to camera settings you can use the Fn button on the back of the camera, and if your lens/es have an iFn button (almost all do except except for the earliest lenses like the 30mm pancake) you can choose various settings such as aperture, ISO or Exposure Compensation to toggle between and then adjust them by turning the focus ring on the lens.
I hope that that was of some help to you. Good luck with your new camera!